The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5.
نویسندگان
چکیده
We have used a cDNA probe for human complement component 9 (C9), which detects three DNA polymorphisms, to analyse the inheritance of C9 in families informative for C6 protein variants. We found that these genes are closely linked with a lod score of 9.28 at recombination fraction 0.00. There is not indication of allelic association.
منابع مشابه
Glutathione-catalyzed disulfide-linking of C9 in the membrane attack complex of complement.
The membrane attack complex of complement (the dimeric C5b-9 complex) is a multimolecular assemblage of five proteins (C5b, C6, C7, C8, and C9) which are held together by noncovalent forces. We found that C9 molecules in the complex can be covalently crosslinked (disulfide-linked) by glutathione. In this experiment, the tetramolecular C5b-8 complex bound to phospholipid vesicles was first prepa...
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عنوان ژورنال:
- Journal of medical genetics
دوره 28 9 شماره
صفحات -
تاریخ انتشار 1991